Phospho-EEF2K (S366) Antibody (PACO00302)
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주문- SKU:
- PACO00302
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-EEF2K (S366) Antibody |
Antibody SKU: | PACO00302 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Rat |
Immunogen: | synthesized peptide derived from human eEF2K around the phosphorylation site of S366. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | EEF2K; Eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase |
UniProt Protein Function: | EEF2K: an atypical protein kinase of the Alpha family. Dependent on Ca2 ions and calmodulin. May play a key role linking cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy. Phosphorylates and inactivates eEF2, resulting in the inhibition of peptide-chain elongation eEF2K is phosphorylated and activated by AMPK in response to elevated AMP levels, which increase during cellular stress and starvation. Regulated in response to a range of stimuli including TNF-alpha. Overexpressed in breast cancer cell lines and tumors. Activated in rat glioblastoma, and growth was inhibited by the drug Rottlerin. Activity induced in ischemic heart muscle |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Translation; Kinase, protein; Protein kinase, atypical; EC 2.7.11.20; ATYPICAL group; Alpha family; eEF2K subfamily Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: cytoplasm; cytosol Molecular Function:calmodulin binding; elongation factor-2 kinase activity; translation factor activity, nucleic acid binding; calcium ion binding; ATP binding; protein kinase activity Biological Process: translational elongation; regulation of protein amino acid autophosphorylation; protein amino acid autophosphorylation; insulin receptor signaling pathway |
NCBI Summary: | This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00418 |
NCBI GenInfo Identifier: | 254763289 |
NCBI Gene ID: | 29904 |
NCBI Accession: | O00418.2 |
UniProt Secondary Accession: | O00418,Q8N588, |
UniProt Related Accession: | O00418 |
Molecular Weight: | 725 |
NCBI Full Name: | Eukaryotic elongation factor 2 kinase |
NCBI Synonym Full Names: | eukaryotic elongation factor 2 kinase |
NCBI Official Symbol: | EEF2K |
NCBI Official Synonym Symbols: | eEF-2K; HSU93850 |
NCBI Protein Information: | eukaryotic elongation factor 2 kinase; eEF-2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase |
UniProt Protein Name: | Eukaryotic elongation factor 2 kinase |
UniProt Synonym Protein Names: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase |
Protein Family: | Eukaryotic elongation factor 2 kinase |
UniProt Gene Name: | EEF2K |
UniProt Entry Name: | EF2K_HUMAN |