Phospho-CTTN (Y466) Antibody (PACO06190)
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주문- SKU:
- PACO06190
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-CTTN (Y466) Antibody (PACO06190) |
Antibody SKU: | PACO06190 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | Synthesized peptide derived from human Cortactin around the phosphorylation site of Y466. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of HELA HepG2 cells using Phospho-Cortactin (Y466) Polyclonal Antibody. | |
Western Blot analysis of 293 cells using Phospho-Cortactin (Y466) Polyclonal Antibody. |
Synonyms: | CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1 |
UniProt Protein Function: | Cortactin: a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches. The central region of the protein contains six repeats of 37 amino acids that are important in F-actin binding and cross-linking. The carboxy-terminus contains a proline-rich region and an SH3 domain that can interact with numerous scaffolding proteins, such as CortBP1 and Shank3. Cortactin may play a role in the organization of transmembrane receptors at postsynaptic densities (PSD) and tight junctions by linking scaffolding proteins to the actin network. It is degraded in a caspase-dependent manner during apoptosis. It is overexpressed in numerous cancers with poor patient prognosis. It may contribute to tumor cell invasion and metastasis. Two splice variant isoforms have been identified. |
UniProt Protein Details: | Protein type:Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: actin filament; cell cortex; coated pit; cortical cytoskeleton; cytoplasm; cytoskeleton; focal adhesion; Golgi apparatus; growth cone; intracellular membrane-bound organelle; lamellipodium; plasma membrane; ruffle; voltage-gated potassium channel complex Molecular Function:profilin binding; protein binding Biological Process: actin cytoskeleton reorganization; cell motility involved in cell locomotion; focal adhesion formation; intracellular protein transport; neurite morphogenesis; positive regulation of actin filament polymerization; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of axon extension |
NCBI Summary: | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] |
UniProt Code: | Q14247 |
NCBI GenInfo Identifier: | 215273892 |
NCBI Gene ID: | 2017 |
NCBI Accession: | Q14247.2 |
UniProt Secondary Accession: | Q14247,Q8N707, Q96H99, |
UniProt Related Accession: | Q14247,AAB26248 |
Molecular Weight: | 57,467 Da |
NCBI Full Name: | Src substrate cortactin |
NCBI Synonym Full Names: | cortactin |
NCBI Official Symbol: | CTTN |
NCBI Official Synonym Symbols: | EMS1 |
NCBI Protein Information: | src substrate cortactin |
UniProt Protein Name: | Src substrate cortactin |
UniProt Synonym Protein Names: | Amplaxin; Oncogene EMS1 |
Protein Family: | CTTNBP2 N-terminal-like protein |
UniProt Gene Name: | CTTN |
UniProt Entry Name: | SRC8_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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