Phospho-CASR (Thr888) Antibody (PACO23958)
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주문- SKU:
- PACO23958
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-CASR (Thr888) Antibody (PACO23958) |
Antibody SKU: | PACO23958 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around phosphorylation site of Threonine 888(R-A-T(p)-L-R) derived from Human Calcium Sensing Receptor. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from LOVO cells using Calcium Sensing Receptor (Phospho-Thr888) Antibody.The lane on the left is treated with the antigen-specific peptide. |
Background: | Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. |
Synonyms: | CAR, FHH, FIH, HHC, EIG8 |
UniProt Protein Function: | CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 3 Chromosomal Location of Human Ortholog: 3q13 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:phosphoinositide phospholipase C activity; protein binding Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; ossification Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I |
NCBI Summary: | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008] |
UniProt Code: | P41180 |
NCBI GenInfo Identifier: | 1168781 |
NCBI Gene ID: | 846 |
NCBI Accession: | P41180.2 |
UniProt Secondary Accession: | P41180,Q13912, Q16108, Q16109, Q16110, Q16379, Q2M1T0 Q4PJ19, |
UniProt Related Accession: | P41180 |
Molecular Weight: | 121,772 Da |
NCBI Full Name: | Extracellular calcium-sensing receptor |
NCBI Synonym Full Names: | calcium sensing receptor |
NCBI Official Symbol: | CASR |
NCBI Official Synonym Symbols: | CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1 |
NCBI Protein Information: | extracellular calcium-sensing receptor |
UniProt Protein Name: | Extracellular calcium-sensing receptor |
UniProt Synonym Protein Names: | Parathyroid cell calcium-sensing receptor 1; PCaR1 |
Protein Family: | Extracellular calcium-sensing receptor |
UniProt Gene Name: | CASR |
UniProt Entry Name: | CASR_HUMAN |
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