Phospho-CAMK4 (Thr196/200) Antibody (PACO24067)
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주문- SKU:
- PACO24067
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-CAMK4 (Thr196/200) Antibody (PACO24067) |
Antibody SKU: | PACO24067 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Peptide sequence around phosphorylation site of threonine 200 (M-K-T(p)-V-C) derived from Human CaMK4 or threonine 196 (M-K-T(p)-V-C) derived from Mouse CaMK4. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from K562 cells treated with H2O2 using Phospho-CaMK4 (Thr196/200) antibody.The lane on the right is treated with the antigen-specific peptide. |
Background: | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). |
Synonyms: | CAM kinase-GR; CAMK4; CaMK IV; Calspermin; KCC4 |
UniProt Protein Function: | CAMK4: a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.17; Kinase, protein; CAMK group; CAMK1 family Chromosomal Location of Human Ortholog: 5q21.3 Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity Biological Process: adaptive immune response; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inflammatory response; innate immune response; long-term memory; myeloid dendritic cell cytokine production; myeloid dendritic cell differentiation; nerve growth factor receptor signaling pathway; nerve-nerve synaptic transmission; nucleocytoplasmic transport; peptidyl-serine phosphorylation; phospholipase C activation; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of osteoclast differentiation; regulation of T cell differentiation in the thymus; signal transduction; synaptic transmission |
NCBI Summary: | The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q16566 |
NCBI GenInfo Identifier: | 2499586 |
NCBI Gene ID: | 814 |
NCBI Accession: | Q16566.1 |
UniProt Secondary Accession: | Q16566,D3DSZ7, |
UniProt Related Accession: | Q16566 |
Molecular Weight: | 51,926 Da |
NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type IV |
NCBI Synonym Full Names: | calcium/calmodulin-dependent protein kinase IV |
NCBI Official Symbol: | CAMK4 |
NCBI Official Synonym Symbols: | caMK; CaMK IV; CaMK-GR |
NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type IV |
UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type IV |
UniProt Synonym Protein Names: | CaM kinase-GR |
Protein Family: | Calcium/calmodulin-dependent protein kinase |
UniProt Gene Name: | CAMK4 |
UniProt Entry Name: | KCC4_HUMAN |
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