Phospho-CALD1 (S789) Antibody (PACO06199)
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주문- SKU:
- PACO06199
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-CALD1 (S789) Antibody (PACO06199) |
Antibody SKU: | PACO06199 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human Caldesmon around the phosphorylation site of S789. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of NIH-3T3 cells using Phospho-Caldesmon (S789) Polyclonal Antibody. | |
Western Blot analysis of 293 cells using Phospho-Caldesmon (S789) Polyclonal Antibody. |
Synonyms: | CALD1; CAD; CDM; Caldesmon; CDM |
UniProt Protein Function: | Caldesmon: a cytoskeletal protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells. May act as a bridge between myosin and actin filaments. Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Five alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 7q33 Cellular Component: actin cap; actin cytoskeleton; cytoskeleton; cytosol; myofibril; plasma membrane Molecular Function:actin binding; calmodulin binding; myosin binding; protein binding; tropomyosin binding Biological Process: cell motility; muscle contraction |
NCBI Summary: | This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q05682 |
NCBI GenInfo Identifier: | 338817891 |
NCBI Gene ID: | 800 |
NCBI Accession: | Q05682.3 |
UniProt Secondary Accession: | Q05682,Q13978, Q13979, Q14741, Q14742, Q9UD91, A8K0X1 |
UniProt Related Accession: | Q05682 |
Molecular Weight: | 65,620 Da |
NCBI Full Name: | Caldesmon |
NCBI Synonym Full Names: | caldesmon 1 |
NCBI Official Symbol: | CALD1 |
NCBI Official Synonym Symbols: | CDM; HCAD; LCAD; H-CAD; L-CAD; NAG22 |
NCBI Protein Information: | caldesmon |
UniProt Protein Name: | Caldesmon |
Protein Family: | Caldesmon |
UniProt Gene Name: | CALD1 |
UniProt Entry Name: | CALD1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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