Phospho-C5AR1 (S338) Antibody (PACO05265)
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주문- SKU:
- PACO05265
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | Phospho-C5AR1 (S338) Antibody (PACO05265) |
Antibody SKU: | PACO05265 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:40000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from human CD88 around the phosphorylation site of S338. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | C5AR1; C5AR; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD antigen CD88 |
UniProt Protein Function: | C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: cell surface; basolateral plasma membrane; integral to plasma membrane; apical part of cell; cytoplasmic membrane-bound vesicle; plasma membrane Molecular Function:complement component C5a binding; complement component C5a receptor activity; C5a anaphylatoxin receptor activity Biological Process: neutrophil chemotaxis; sensory perception of chemical stimulus; organ regeneration; apoptosis; activation of MAPK activity; response to lipopolysaccharide; cell proliferation in hindbrain; signal transduction; chemotaxis; mRNA transcription from RNA polymerase II promoter; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; phospholipase C activation; response to peptidoglycan; cellular defense response; immune response; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation |
UniProt Code: | P21730 |
NCBI GenInfo Identifier: | 311033355 |
NCBI Gene ID: | 728 |
NCBI Accession: | P21730.2 |
UniProt Related Accession: | P21730 |
Molecular Weight: | 39,336 Da |
NCBI Full Name: | C5a anaphylatoxin chemotactic receptor 1 |
NCBI Synonym Full Names: | complement component 5a receptor 1 |
NCBI Official Symbol: | C5AR1 |
NCBI Official Synonym Symbols: | C5A; C5AR; C5R1; CD88 |
NCBI Protein Information: | C5a anaphylatoxin chemotactic receptor 1; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1 |
UniProt Protein Name: | C5a anaphylatoxin chemotactic receptor 1 |
UniProt Synonym Protein Names: | C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88 |
Protein Family: | C5a anaphylatoxin chemotactic receptor |
UniProt Gene Name: | C5AR1 |
UniProt Entry Name: | C5AR1_HUMAN |