Phospho-ARAF (Y302) Antibody (PACO05934)
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주문- SKU:
- PACO05934
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-ARAF (Y302) Antibody (PACO05934) |
Antibody SKU: | PACO05934 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from human A-Raf around the phosphorylation site of Y302. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ARAF; ARAF1; PKS; PKS2; Serine/threonine-protein kinase A-Raf; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks |
UniProt Protein Function: | ARAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; TKL group; RAF family Chromosomal Location of Human Ortholog: Xp11.4-p11.2 Cellular Component: cytosol Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: MAPKKK cascade; negative regulation of apoptosis; positive regulation of peptidyl-serine phosphorylation; protein modification process; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway |
NCBI Summary: | This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012] |
UniProt Code: | P10398 |
NCBI GenInfo Identifier: | 1730068 |
NCBI Gene ID: | 369 |
NCBI Accession: | P10398.2 |
UniProt Secondary Accession: | P10398,P07557, Q5H9B2, Q5H9B3, |
UniProt Related Accession: | P10398 |
Molecular Weight: | 20,904 Da |
NCBI Full Name: | Serine/threonine-protein kinase A-Raf |
NCBI Synonym Full Names: | A-Raf proto-oncogene, serine/threonine kinase |
NCBI Official Symbol: | ARAF |
NCBI Official Synonym Symbols: | PKS2; A-RAF; ARAF1; RAFA1 |
NCBI Protein Information: | serine/threonine-protein kinase A-Raf |
UniProt Protein Name: | Serine/threonine-protein kinase A-Raf |
UniProt Synonym Protein Names: | Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks |
Protein Family: | ABC transporter L-arabinose-binding periplasmic protein |
UniProt Gene Name: | ARAF |
UniProt Entry Name: | ARAF_HUMAN |