Phospho-ACAP1 (S554) Antibody (PACO05811)
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주문- SKU:
- PACO05811
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-ACAP1 (S554) Antibody (PACO05811) |
Antibody SKU: | PACO05811 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:40000, IHC:1:100-1:300 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from human ACAP1 around the phosphorylation site of S554. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | ACAP1; CENTB1; KIAA0050; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1; Centaurin-β-1; Cnt-b1 |
UniProt Protein Function: | CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol. |
UniProt Protein Details: | Protein type:GAPs, ARF; GAPs; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: membrane Molecular Function:protein binding |
UniProt Code: | Q15027 |
NCBI GenInfo Identifier: | 3183210 |
NCBI Gene ID: | 9744 |
NCBI Accession: | Q15027.1 |
UniProt Secondary Accession: | Q15027,Q53XN9, |
UniProt Related Accession: | Q15027 |
Molecular Weight: | 81,536 Da |
NCBI Full Name: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
NCBI Synonym Full Names: | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
NCBI Official Symbol: | ACAP1 |
NCBI Official Synonym Symbols: | CENTB1 |
NCBI Protein Information: | arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
UniProt Protein Name: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
UniProt Synonym Protein Names: | Centaurin-beta-1; Cnt-b1 |
Protein Family: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein |
UniProt Gene Name: | ACAP1 |
UniProt Entry Name: | ACAP1_HUMAN |