PHLDA3 Antibody (PACO49870)
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주문- SKU:
- PACO49870
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PHLDA3 Antibody (PACO49870) |
Antibody SKU: | PACO49870 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of PC-3 cells using PACO49870 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. |
Synonyms: | Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1), PHLDA3, TIH1 |
UniProt Protein Function: | PHLDA3: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. Belongs to the PHLDA3 family. Induced by p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter. |
UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytoplasm; plasma membrane Molecular Function:phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-5-phosphate binding Biological Process: anatomical structure morphogenesis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of protein kinase B signaling cascade; positive regulation of apoptosis |
UniProt Code: | Q9Y5J5 |
NCBI GenInfo Identifier: | 74735291 |
NCBI Gene ID: | 23612 |
NCBI Accession: | Q9Y5J5.1 |
UniProt Secondary Accession: | Q9Y5J5,Q53HD6, Q8NBW9, B2R5A4, |
UniProt Related Accession: | Q9Y5J5 |
Molecular Weight: | |
NCBI Full Name: | Pleckstrin homology-like domain family A member 3 |
NCBI Synonym Full Names: | pleckstrin homology like domain family A member 3 |
NCBI Official Symbol: | PHLDA3 |
NCBI Official Synonym Symbols: | TIH1 |
NCBI Protein Information: | pleckstrin homology-like domain family A member 3 |
UniProt Protein Name: | Pleckstrin homology-like domain family A member 3 |
UniProt Synonym Protein Names: | TDAG51/Ipl homolog 1 |
Protein Family: | Pleckstrin homology-like domain family |
UniProt Gene Name: | PHLDA3 |
UniProt Entry Name: | PHLA3_HUMAN |