PHGDH Antibody (PACO20221)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO20221
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | PHGDH Antibody (PACO20221) |
Antibody SKU: | PACO20221 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human PHGDH |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: 293T cells, Primary antibody: PACO20221(PHGDH Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid, synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. |
Synonyms: | phosphoglycerate dehydrogenase |
UniProt Protein Function: | PHGDH: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation, and seizures. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
UniProt Protein Details: | Protein type:Oxidoreductase; Amino Acid Metabolism - glycine, serine and threonine; EC 1.1.1.95; Cell development/differentiation Chromosomal Location of Human Ortholog: 1p12 Cellular Component: cytosol Molecular Function:electron carrier activity; NAD binding; phosphoglycerate dehydrogenase activity Biological Process: neural tube development; glial cell development; glycine metabolic process; gamma-aminobutyric acid metabolic process; glutamine metabolic process; L-serine biosynthetic process; spinal cord development; regulation of gene expression; amino acid biosynthetic process; brain development; taurine metabolic process; neurite development; threonine metabolic process Disease: Phosphoglycerate Dehydrogenase Deficiency; Neu-laxova Syndrome 1 |
NCBI Summary: | This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011] |
UniProt Code: | O43175 |
NCBI GenInfo Identifier: | 21264510 |
NCBI Gene ID: | 26227 |
NCBI Accession: | O43175.4 |
UniProt Secondary Accession: | O43175,Q5SZU3, Q9BQ01, B2RD08, |
UniProt Related Accession: | O43175 |
Molecular Weight: | 533 |
NCBI Full Name: | D-3-phosphoglycerate dehydrogenase |
NCBI Synonym Full Names: | phosphoglycerate dehydrogenase |
NCBI Official Symbol: | PHGDH |
NCBI Official Synonym Symbols: | NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113 |
NCBI Protein Information: | D-3-phosphoglycerate dehydrogenase; epididymis secretory protein Li 113 |
UniProt Protein Name: | D-3-phosphoglycerate dehydrogenase |
UniProt Gene Name: | PHGDH |
UniProt Entry Name: | SERA_HUMAN |
Antibodies | ELISA Kits |
Anti-PHGDH Antibody (CAB10461) | Human D-3-phosphoglycerate dehydrogenase (PHGDH) ELISA Kit |
Anti-PHGDH Antibody (CAB19974)[KO Validated] | |
PHGDH Antibody (PACO11214) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |