PGK1 Antibody (PACO15756)
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주문- SKU:
- PACO15756
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PGK1 Antibody (PACO15756) |
Antibody SKU: | PACO15756 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PGK1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15756(PGK1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cells, mouse liver tissue, hepG2 cells, Primary antibody: PACO15756(PGK1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15756(PGK1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. |
Synonyms: | phosphoglycerate kinase 1 |
UniProt Protein Function: | PGK1: an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein). |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; EC 2.7.2.3 Chromosomal Location of Human Ortholog: Xq13.3 Cellular Component: membrane; cytosol Molecular Function:protein binding; phosphoglycerate kinase activity; ATP binding Biological Process: glycolysis; epithelial cell differentiation; carbohydrate metabolic process; glucose metabolic process; pathogenesis; phosphorylation; gluconeogenesis Disease: Phosphoglycerate Kinase 1 Deficiency |
NCBI Summary: | The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014] |
UniProt Code: | P00558 |
NCBI GenInfo Identifier: | 52788229 |
NCBI Gene ID: | 5230 |
NCBI Accession: | P00558.3 |
UniProt Secondary Accession: | P00558,Q5J7W1, Q6IBT6, Q8NI87, A8K4W6, B7Z7A9, |
UniProt Related Accession: | P00558 |
Molecular Weight: | 417 |
NCBI Full Name: | Phosphoglycerate kinase 1 |
NCBI Synonym Full Names: | phosphoglycerate kinase 1 |
NCBI Official Symbol: | PGK1 |
NCBI Official Synonym Symbols: | PGKA; MIG10; HEL-S-68p |
NCBI Protein Information: | phosphoglycerate kinase 1; PRP 2; primer recognition protein 2; cell migration-inducing gene 10 protein; epididymis secretory sperm binding protein Li 68p |
UniProt Protein Name: | Phosphoglycerate kinase 1 |
UniProt Synonym Protein Names: | Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2 |
Protein Family: | Phosphoglycerate kinase |
UniProt Gene Name: | PGK1 |
UniProt Entry Name: | PGK1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |