PELI3 Antibody (PACO45253)
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주문- SKU:
- PACO45253
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PELI3 Antibody (PACO45253) |
Antibody SKU: | PACO45253 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human E3 ubiquitin-protein ligase pellino homolog 3 protein (1-280AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO45253 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human melanoma using PACO45253 at dilution of 1:100. |
Background: | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. |
Synonyms: | E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 3), PELI3 |
UniProt Protein Function: | PELI3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: cytosol Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: immune response; Toll signaling pathway |
NCBI Summary: | The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
UniProt Code: | Q8N2H9 |
NCBI GenInfo Identifier: | 37999712 |
NCBI Gene ID: | 246330 |
NCBI Accession: | Q8N2H9.2 |
UniProt Secondary Accession: | Q8N2H9,Q8N3E1, Q8N9Q6, Q8TAW7, Q8TED5, |
UniProt Related Accession: | Q8N2H9 |
Molecular Weight: | 51kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase pellino homolog 3 |
NCBI Synonym Full Names: | pellino E3 ubiquitin protein ligase family member 3 |
NCBI Official Symbol: | PELI3 |
NCBI Protein Information: | E3 ubiquitin-protein ligase pellino homolog 3 |
UniProt Protein Name: | E3 ubiquitin-protein ligase pellino homolog 3 |
UniProt Synonym Protein Names: | RING-type E3 ubiquitin transferase pellino homolog 3Curated |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | PELI3 |
Antibodies |
Anti-PELI3 Antibody (CAB9999) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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