PEG10 Antibody (PACO14865)
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주문- SKU:
- PACO14865
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PEG10 Antibody (PACO14865) |
Antibody SKU: | PACO14865 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human PEG10 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, A549 cells, Primary antibody: PACO14865(PEG10 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. |
Synonyms: | paternally expressed 10 |
UniProt Protein Function: | PEG10: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Up-regulated by MYC and dihydrotestosteron (DHT). Interacts with ALK1, SIAH1 and SIAH2. 2 isoforms of the human protein are produced by ribosomal frameshifting. |
UniProt Protein Details: | Protein type:RNA-binding; Cell cycle regulation; Apoptosis; Cell development/differentiation Chromosomal Location of Human Ortholog: 7q21 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding Biological Process: apoptosis; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway |
UniProt Code: | Q86TG7 |
NCBI GenInfo Identifier: | 172046699 |
NCBI Gene ID: | |
NCBI Accession: | Q86TG7.2 |
Molecular Weight: | 55kDa |
NCBI Full Name: | Retrotransposon-derived protein PEG10 |
UniProt Protein Name: | Retrotransposon-derived protein PEG10 |
UniProt Synonym Protein Names: | Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein |
Protein Family: | Retrotransposon-derived protein |
UniProt Gene Name: | PEG10 |
UniProt Entry Name: | PEG10_HUMAN |
Antibodies | ELISA Kits |
Anti-PEG10 Antibody (CAB2787) | Human PEG10 / EDR ELISA Kit |
PEG10 Antibody (PACO11164) | Human Retrotransposon-derived protein PEG10 (PEG10) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |