PDE6D Antibody (PACO35138)
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주문- SKU:
- PACO35138
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PDE6D Antibody (PACO35138) |
Antibody SKU: | PACO35138 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta protein (1-150AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: PDE6D antibody at 1.5µg/ml. Lane 1: A549 whole cell lysate. Lane 2: MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 18 kDa. Observed band size: 18 kDa. | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO35138 at dilution of 1:100. |
Background: | Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). |
Synonyms: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17), PDE6D, PDED |
UniProt Protein Function: | PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q35-q36 Cellular Component: cytoplasmic vesicle; cytosol Molecular Function:GTPase inhibitor activity; protein binding; Rab GTPase binding Disease: Joubert Syndrome 22 |
NCBI Summary: | This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014] |
UniProt Code: | O43924 |
NCBI GenInfo Identifier: | 5921809 |
NCBI Gene ID: | 5147 |
NCBI Accession: | O43924.1 |
UniProt Secondary Accession: | O43924,O43250, |
UniProt Related Accession: | O43924 |
Molecular Weight: | 17,420 Da |
NCBI Full Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
NCBI Synonym Full Names: | phosphodiesterase 6D |
NCBI Official Symbol: | PDE6D |
NCBI Official Synonym Symbols: | PDED; JBTS22 |
NCBI Protein Information: | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
UniProt Protein Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
UniProt Synonym Protein Names: | Protein p17 |
Protein Family: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase |
UniProt Gene Name: | PDE6D |
UniProt Entry Name: | PDE6D_HUMAN |
Antibodies |
Anti-PDE6D Antibody (CAB14762) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |