PDE10A Antibody (PACO03297)
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주문- SKU:
- PACO03297
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PDE10A Antibody |
Antibody SKU: | PACO03297 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Rat |
Immunogen: | synthesized peptide derived from the N-terminal region of human PDE10A. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | PDE10A; cAMP and cAMP-inhibited cGMP 3'; 5'-cyclic phosphodiesterase 10A |
UniProt Protein Function: | PDE10A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17; EC 3.1.4.35 Chromosomal Location of Human Ortholog: 6q26 Cellular Component: cytosol Molecular Function:3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cGMP binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity Biological Process: cAMP catabolic process; cGMP catabolic process; blood coagulation; signal transduction |
NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9Y233 |
NCBI GenInfo Identifier: | 7993747 |
NCBI Gene ID: | 10846 |
NCBI Accession: | Q9Y233.1 |
UniProt Secondary Accession: | Q9Y233,Q6FHX1, Q9HCP9, Q9NTV4, Q9ULW9, Q9Y5T1, |
UniProt Related Accession: | Q9Y233 |
Molecular Weight: | 89,390 Da |
NCBI Full Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
NCBI Synonym Full Names: | phosphodiesterase 10A |
NCBI Official Symbol: | PDE10A |
NCBI Official Synonym Symbols: | HSPDE10A |
NCBI Protein Information: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); phosphodiesterase 10A1 (PDE10A1) |
UniProt Protein Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A |
Protein Family: | cGMP-gated cation channel |
UniProt Gene Name: | PDE10A |
UniProt Entry Name: | PDE10_HUMAN |