PCK2 Antibody (PACO16686)
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주문- SKU:
- PACO16686
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PCK2 Antibody (PACO16686) |
Antibody SKU: | PACO16686 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | Fusion protein of human PCK2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16686(PCK2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, Jurkat cells, Hela cells, Primary antibody: PACO16686(PCK2 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16686(PCK2 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. |
Synonyms: | phosphoenolpyruvate carboxykinase 2 |
UniProt Protein Function: | PCK2: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Monomer. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 4.1.1.32; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Lyase Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity; protein binding Biological Process: gluconeogenesis Disease: Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial |
NCBI Summary: | This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q16822 |
NCBI GenInfo Identifier: | 290457671 |
NCBI Gene ID: | 5106 |
NCBI Accession: | Q16822.3 |
UniProt Secondary Accession: | Q16822,O43253, Q86U01, Q9BV62, |
UniProt Related Accession: | Q16822 |
Molecular Weight: | 47,564 Da |
NCBI Full Name: | Phosphoenolpyruvate carboxykinase |
NCBI Synonym Full Names: | phosphoenolpyruvate carboxykinase 2, mitochondrial |
NCBI Official Symbol: | PCK2 |
NCBI Official Synonym Symbols: | PEPCK; PEPCK2; PEPCK-M |
NCBI Protein Information: | phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
UniProt Protein Name: | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
Protein Family: | Protein kinase |
UniProt Gene Name: | PCK2 |
UniProt Entry Name: | PCKGM_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |