PCGF6 Antibody (PACO60352)
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주문- SKU:
- PACO60352
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PCGF6 Antibody (PACO60352) |
Antibody SKU: | PACO60352 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: PC-3 whole cell lysate, MCF-7 whole cell lysate. All lanes: PCGF6 antibody at 3.1µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 31 kDa. Observed band size: 40 kDa. |
Background: | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Synonyms: | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134), PCGF6, MBLR RNF134 |
UniProt Protein Function: | MBLR: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 10q24.33 Cellular Component: nucleus; PcG protein complex Molecular Function:DNA binding; protein binding; transcription factor activity Biological Process: negative regulation of transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BYE7 |
NCBI GenInfo Identifier: | 116242703 |
NCBI Gene ID: | 84108 |
NCBI Accession: | Q9BYE7.2 |
UniProt Secondary Accession: | Q9BYE7,Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1, A8K3R4, |
UniProt Related Accession: | Q9BYE7 |
Molecular Weight: | 30,249 Da |
NCBI Full Name: | Polycomb group RING finger protein 6 |
NCBI Synonym Full Names: | polycomb group ring finger 6 |
NCBI Official Symbol: | PCGF6 |
NCBI Official Synonym Symbols: | MBLR; RNF134 |
NCBI Protein Information: | polycomb group RING finger protein 6 |
UniProt Protein Name: | Polycomb group RING finger protein 6 |
UniProt Synonym Protein Names: | Mel18 and Bmi1-like RING finger; RING finger protein 134 |
Protein Family: | Polycomb group RING finger protein |
UniProt Gene Name: | PCGF6 |
UniProt Entry Name: | PCGF6_HUMAN |
Antibodies | ELISA Kits |
Anti-PCGF6 Antibody (CAB5760) | Human PCGF6 / Polycomb group RING finger protein 6 ELISA Kit |
Human Polycomb group RING finger protein 6 (PCGF6) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |