PC Antibody (PACO14857)
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주문- SKU:
- PACO14857
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PC Antibody (PACO14857) |
Antibody SKU: | PACO14857 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PC |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, human liver cancer tissue, Primary antibody: PACO14857(PC Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
Background: | This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. |
Synonyms: | Pyruvate carboxylase |
UniProt Protein Function: | PC: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency). PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia. |
UniProt Protein Details: | Protein type:EC 6.4.1.1; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Ligase Chromosomal Location of Human Ortholog: 11q13.4-q13.5 Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion Molecular Function:protein binding; pyruvate carboxylase activity Biological Process: biotin metabolic process; gluconeogenesis; viral RNA genome packaging Disease: Pyruvate Carboxylase Deficiency |
NCBI Summary: | This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P11498 |
NCBI GenInfo Identifier: | 1709947 |
NCBI Gene ID: | 5091 |
NCBI Accession: | P11498.2 |
UniProt Secondary Accession: | P11498,Q16705, B4DN00, |
UniProt Related Accession: | P11498 |
Molecular Weight: | 57,925 Da |
NCBI Full Name: | Pyruvate carboxylase, mitochondrial |
NCBI Synonym Full Names: | pyruvate carboxylase |
NCBI Official Symbol: | PC |
NCBI Official Synonym Symbols: | PCB |
NCBI Protein Information: | pyruvate carboxylase, mitochondrial |
UniProt Protein Name: | Pyruvate carboxylase, mitochondrial |
UniProt Synonym Protein Names: | Pyruvic carboxylase; PCB |
Protein Family: | PCTP-like protein |
UniProt Gene Name: | PC |
UniProt Entry Name: | PYC_HUMAN |
Antibodies | ELISA Kits |
Anti-PC Antibody (CAB6301) | Human Pyruvate carboxylase, mitochondrial (PC) ELISA Kit |
Anti-PCB Antibody (CAB8980) | |
PC Antibody (PACO04512) | |
PC Antibody (PACO11088) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |