PAX8 Antibody (PACO11084)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO11084
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PAX8 Antibody (PACO11084) |
Antibody SKU: | PACO11084 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human PAX8 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | paired box 8; |
UniProt Protein Function: | PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q13 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity Biological Process: regulation of apoptosis; anatomical structure morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; positive regulation of transcription from RNA polymerase II promoter; mesonephros development; kidney development; pronephros development; urogenital system development Disease: Hypothyroidism, Congenital, Nongoitrous, 2 |
NCBI Summary: | This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q06710 |
NCBI GenInfo Identifier: | 215273928 |
NCBI Gene ID: | 7849 |
NCBI Accession: | Q06710.2 |
UniProt Related Accession: | Q06710 |
Molecular Weight: | 48kDa |
NCBI Full Name: | Paired box protein Pax-8 |
NCBI Synonym Full Names: | paired box 8 |
NCBI Official Symbol: | PAX8 |
NCBI Protein Information: | paired box protein Pax-8 |
UniProt Protein Name: | Paired box protein Pax-8 |
Protein Family: | Paired box protein |
UniProt Gene Name: | PAX8 |
UniProt Entry Name: | PAX8_HUMAN |