PARP4 Antibody (PACO20172)
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주문- SKU:
- PACO20172
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PARP4 Antibody (PACO20172) |
Antibody SKU: | PACO20172 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human PARP4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20172(PARP4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20172(PARP4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. |
Synonyms: | poly (ADP-ribose) polymerase family, member 4 |
UniProt Protein Function: | PARP4: Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1. |
UniProt Protein Details: | Protein type:Transferase; EC 2.4.2.30 Chromosomal Location of Human Ortholog: 13q11 Cellular Component: membrane; spindle microtubule; cytoplasm; ribonucleoprotein complex; nucleus Molecular Function:protein binding; enzyme binding; DNA binding; NAD+ ADP-ribosyltransferase activity Biological Process: response to drug; cell death; protein amino acid ADP-ribosylation; transport; protein modification process; DNA repair; inflammatory response; response to DNA damage stimulus |
NCBI Summary: | This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UKK3 |
NCBI GenInfo Identifier: | 112789550 |
NCBI Gene ID: | 143 |
NCBI Accession: | NP_006428.2 |
UniProt Secondary Accession: | Q9UKK3,O75903, Q14682, Q5QNZ9, Q9H1M6, |
UniProt Related Accession: | Q9UKK3 |
Molecular Weight: | 192,595 Da |
NCBI Full Name: | poly |
NCBI Synonym Full Names: | poly (ADP-ribose) polymerase family, member 4 |
NCBI Official Symbol: | PARP4 |
NCBI Official Synonym Symbols: | PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1 |
NCBI Protein Information: | poly [ADP-ribose] polymerase 4; poly [ADP-ribose] polymerase 4; 193 kDa vault protein; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1; ADP-ribosyltransferase diphtheria toxin-like 4; H5 proline-rich; I-alpha-I-related; PARP-related; PARP-related/IalphaI-related H5/proline-rich; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase-like 1; vault poly(ADP-ribose) polymerase; vault protein, 193-kDa; von Willebrand factor A domain containing 5C |
UniProt Protein Name: | Poly [ADP-ribose] polymerase 4 |
UniProt Synonym Protein Names: | 193 kDa vault protein; ADP-ribosyltransferase diphtheria toxin-like 4; ARTD4; PARP-related/IalphaI-related H5/proline-rich; PH5P; Vault poly(ADP-ribose) polymerase; VPARP |
Protein Family: | Poly [ADP-ribose] polymerase |
UniProt Gene Name: | PARP4 |
UniProt Entry Name: | PARP4_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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