PARP2 Antibody (PACO55270)
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주문- SKU:
- PACO55270
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PARP2 Antibody (PACO55270) |
Antibody SKU: | PACO55270 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Poly [ADP-ribose] polymerase 2 protein (14-149AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: PC-3 whole cell lysate, HepG2 whole cell lysate. All lanes: PARP2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 67, 65 kDa. Observed band size: 67 kDa. |
Background: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity. |
Synonyms: | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2), PARP2, ADPRT2 ADPRTL2 |
UniProt Protein Function: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). |
NCBI Summary: | This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UGN5 |
NCBI GenInfo Identifier: | 110825961 |
NCBI Gene ID: | 10038 |
NCBI Accession: | NP_005475 |
UniProt Secondary Accession: | Q9UGN5,Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8, |
UniProt Related Accession: | Q9UGN5 |
Molecular Weight: | 42.5 kDa (376aa) |
NCBI Full Name: | poly |
NCBI Synonym Full Names: | poly(ADP-ribose) polymerase 2 |
NCBI Official Symbol: | PARP2 |
NCBI Official Synonym Symbols: | ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2 |
NCBI Protein Information: | poly [ADP-ribose] polymerase 2 |
UniProt Protein Name: | Poly [ADP-ribose] polymerase 2 |
UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 2; ARTD2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; Poly[ADP-ribose] synthase 2; pADPRT-2 |
Protein Family: | Poly [ADP-ribose] polymerase |
UniProt Gene Name: | PARP2 |
Antibodies | ELISA Kits |
Anti-PARP2 Antibody (CAB16475) | Human PARP2 ELISA Kit |
PARP2 Antibody (PACO02288) | Human Poly [ADP-ribose] polymerase 2 (PARP2) ELISA Kit |
PARP2 Antibody (PACO11076) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |