PARD6A Antibody (PACO14842)
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주문- SKU:
- PACO14842
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PARD6A Antibody (PACO14842) |
Antibody SKU: | PACO14842 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human PARD6A |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14842(PARD6A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO14842(PARD6A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Synonyms: | par-6 family cell polarity regulator alpha |
UniProt Protein Function: | PARD6A: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Interacts with MAP2K5. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr- 359' phosphorylated form) and PRKCI. Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. Belongs to the PAR6 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: ruffle; protein complex; tight junction; apical part of cell; plasma membrane; cell cortex; nucleus; cytosol Molecular Function:protein binding; Rho GTPase binding; protein kinase C binding; GTP-dependent protein binding; transcription factor binding Biological Process: intercellular junction assembly and maintenance; viral reproduction; cell division; transforming growth factor beta receptor signaling pathway; intercellular junction maintenance; cell cycle |
NCBI Summary: | This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NPB6 |
NCBI GenInfo Identifier: | 30913215 |
NCBI Gene ID: | 50855 |
NCBI Accession: | Q9NPB6.1 |
UniProt Related Accession: | Q9NPB6 |
Molecular Weight: | 37kDa |
NCBI Full Name: | Partitioning defective 6 homolog alpha |
NCBI Synonym Full Names: | par-6 family cell polarity regulator alpha |
NCBI Official Symbol: | PARD6A |
NCBI Official Synonym Symbols: | PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha |
NCBI Protein Information: | partitioning defective 6 homolog alpha |
UniProt Protein Name: | Partitioning defective 6 homolog alpha |
UniProt Synonym Protein Names: | PAR6C; Tax interaction protein 40; TIP-40 |
UniProt Gene Name: | PARD6A |
UniProt Entry Name: | PAR6A_HUMAN |