PAN2 Antibody (PACO46582)
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주문- SKU:
- PACO46582
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PAN2 Antibody (PACO46582) |
Antibody SKU: | PACO46582 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit PAN2 protein (628-908AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO46582 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO46582 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. |
Synonyms: | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2), PAN2, KIAA0710 USP52 |
UniProt Protein Function: | USP52: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein. Belongs to the peptidase C19 family. PAN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ribonuclease; EC 3.1.13.4; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 12q13.2 Cellular Component: cytosol Molecular Function:3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; protein binding Biological Process: poly(A) tail shortening |
NCBI Summary: | This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q504Q3 |
NCBI GenInfo Identifier: | 296439280 |
NCBI Gene ID: | 9924 |
NCBI Accession: | Q504Q3.3 |
UniProt Secondary Accession: | Q504Q3,O75189, Q76E12, Q8IVE1, |
UniProt Related Accession: | Q504Q3 |
Molecular Weight: | 135,281 Da |
NCBI Full Name: | PAB-dependent poly(A)-specific ribonuclease subunit PAN2 |
NCBI Synonym Full Names: | PAN2 poly(A) specific ribonuclease subunit |
NCBI Official Symbol: | PAN2 |
NCBI Official Synonym Symbols: | USP52 |
NCBI Protein Information: | PAB-dependent poly(A)-specific ribonuclease subunit PAN2 |
UniProt Protein Name: | PAB-dependent poly(A)-specific ribonuclease subunit PAN2 |
UniProt Synonym Protein Names: | Inactive ubiquitin carboxyl-terminal hydrolase 52 |
Protein Family: | Proteasome-activating nucleotidase |
UniProt Gene Name: | PAN2 |
UniProt Entry Name: | PAN2_HUMAN |