PAK6 Antibody (PACO43755)
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주문- SKU:
- PACO43755
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PAK6 Antibody (PACO43755) |
Antibody SKU: | PACO43755 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Serine/threonine-protein kinase PAK 6 protein (1-270AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43755 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO43755 at dilution of 1:100. |
Background: | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. |
Synonyms: | Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6), PAK6, PAK5 |
UniProt Protein Function: | PAK6: a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.11.1; STE group; STE20 family; PAKB subfamily Chromosomal Location of Human Ortholog: 15q14 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
UniProt Code: | Q9NQU5 |
NCBI GenInfo Identifier: | 23396789 |
NCBI Gene ID: | 56924 |
NCBI Accession: | Q9NQU5.1 |
UniProt Secondary Accession: | Q9NQU5,A8K2G2, B3KYB0, G5E9R2, |
UniProt Related Accession: | Q9NQU5 |
Molecular Weight: | 681 |
NCBI Full Name: | Serine/threonine-protein kinase PAK 6 |
NCBI Synonym Full Names: | p21 protein (Cdc42/Rac)-activated kinase 6 |
NCBI Official Symbol: | PAK6 |
NCBI Official Synonym Symbols: | PAK5 |
NCBI Protein Information: | serine/threonine-protein kinase PAK 6; p21(CDKN1A)-activated kinase 6 |
UniProt Protein Name: | Serine/threonine-protein kinase PAK 6 |
UniProt Synonym Protein Names: | PAK-5; p21-activated kinase 6; PAK-6 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | PAK6 |
UniProt Entry Name: | PAK6_HUMAN |