PAG1 Antibody (PACO47202)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO47202
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | PAG1 Antibody (PACO47202) |
Antibody SKU: | PACO47202 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 protein (97-432AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human glioma using PACO47202 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO47202 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human lung tissue using PACO47202 at dilution of 1:100. |
Background: | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. |
Synonyms: | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp), PAG1, CBP PAG |
UniProt Protein Function: | PAG: an ubiquitous type III transmembrane adaptor protein that binds to the tyrosine kinase CSK protein. It is thought to be involved in the regulation of T cell activation. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Adaptor/scaffold Chromosomal Location of Human Ortholog: 8q21.13 Cellular Component: plasma membrane; integral to membrane; lipid raft Molecular Function:protein binding; SH3/SH2 adaptor activity; SH2 domain binding Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of signal transduction; signal transduction; negative regulation of T cell activation; T cell receptor signaling pathway; regulation of T cell activation |
NCBI Summary: | The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NWQ8 |
NCBI GenInfo Identifier: | 63054864 |
NCBI Gene ID: | 55824 |
NCBI Accession: | NP_060910.3 |
UniProt Secondary Accession: | Q9NWQ8,Q3U1F9, Q9JM80, |
UniProt Related Accession: | Q9NWQ8 |
Molecular Weight: | 46,981 Da |
NCBI Full Name: | phosphoprotein associated with glycosphingolipid-enriched microdomains 1 |
NCBI Synonym Full Names: | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
NCBI Official Symbol: | PAG1 |
NCBI Official Synonym Symbols: | CBP; PAG |
NCBI Protein Information: | phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Csk-binding protein; phosphoprotein associated with glycosphingolipid microdomains 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprot |
UniProt Protein Name: | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 |
UniProt Synonym Protein Names: | Csk-binding protein; Transmembrane adapter protein PAG; Transmembrane phosphoprotein Cbp |
Protein Family: | CBP3-like protein |
UniProt Gene Name: | PAG1 |
UniProt Entry Name: | PHAG1_HUMAN |