P2RX7 Antibody (PACO62807)
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주문- SKU:
- PACO62807
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | P2RX7 Antibody (PACO62807) |
Antibody SKU: | PACO62807 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human P2X purinoceptor 7 protein (110-247AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescence staining of Hela cells with PACO62807 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. |
Synonyms: | P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor), P2RX7 |
UniProt Protein Function: | P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation. |
UniProt Protein Details: | Protein type:Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; integral to nuclear inner membrane; integral to plasma membrane; membrane; plasma membrane Molecular Function:ATP binding; ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; purinergic nucleotide receptor activity; receptor binding Biological Process: bleb formation; blood coagulation; cell surface receptor linked signal transduction; membrane depolarization; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phospholipid scrambling; pore complex biogenesis; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization and biogenesis; positive regulation of glycolysis; positive regulation of interleukin-1 beta secretion; regulation of sodium ion transport; response to ATP; sensory perception of pain Disease: Leukemia, Chronic Lymphocytic |
NCBI Summary: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010] |
UniProt Code: | Q99572 |
NCBI GenInfo Identifier: | 395398617 |
NCBI Gene ID: | 5027 |
NCBI Accession: | Q99572.4 |
UniProt Secondary Accession: | Q99572,O14991, Q4VKH8, Q4VKH9, Q4VKI0, Q4VKI1, Q4VKI2 A8K2Z0, E7EMK6, F5H6P2, F5H7E8, F8W951, |
UniProt Related Accession: | Q99572 |
Molecular Weight: | 69kDa |
NCBI Full Name: | P2X purinoceptor 7 |
NCBI Synonym Full Names: | purinergic receptor P2X 7 |
NCBI Official Symbol: | P2RX7 |
NCBI Official Synonym Symbols: | P2X7 |
NCBI Protein Information: | P2X purinoceptor 7 |
UniProt Protein Name: | P2X purinoceptor 7 |
UniProt Synonym Protein Names: | ATP receptor; P2Z receptor; Purinergic receptor |
Protein Family: | P2X purinoceptor |
UniProt Gene Name: | P2RX7 |
Antibodies | ELISA Kits |
Anti-P2RX7 Antibody (CAB10511) | Human P2RX7 / P2X purinoceptor 7 ELISA Kit |
P2RX7 Antibody (PACO11039) | Human P2X purinoceptor 7 (P2RX7) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |