P2RX4 Antibody (PACO50970)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO50970
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | P2RX4 Antibody (PACO50970) |
Antibody SKU: | PACO50970 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human P2X purinoceptor 4 protein (91-176AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse brain tissue, Mouse kidney tissue, Mouse liver tissue, Rat lung tissue, Rat skeletal muscle tissue. All lanes: P2RX4 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 44, 46, 41 kDa. Observed band size: 44 kDa.. | |
Immunohistochemistry of paraffin-embedded human lung tissue using PACO50970 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO50970 at dilution of 1:100. |
Background: | Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. |
Synonyms: | P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor), P2RX4 |
UniProt Protein Function: | P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.32 Cellular Component: membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; lysosomal membrane; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane; terminal button; integral to nuclear inner membrane; cell junction Molecular Function:protein homodimerization activity; copper ion binding; zinc ion binding; cadherin binding; drug binding; ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity; receptor binding Biological Process: positive regulation of nitric oxide biosynthetic process; generation of action potential; positive regulation of calcium-mediated signaling; regulation of sodium ion transport; sensory perception of pain; signal transduction; vasodilation; response to ATP; endothelial cell activation; membrane depolarization; transport; calcium ion transport; regulation of blood pressure; positive regulation of prostaglandin secretion; tissue homeostasis; regulation of excitatory postsynaptic membrane potential; positive regulation of calcium ion transport; nitric oxide biosynthetic process; protein homooligomerization |
NCBI Summary: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q99571 |
NCBI GenInfo Identifier: | 116242696 |
NCBI Gene ID: | 5025 |
NCBI Accession: | Q99571.2 |
UniProt Related Accession: | Q99571 |
Molecular Weight: | Predicted Molecular Mass: 33.2kDaAccurate Molecular Mass: 33kDa as determined by SDS-PAGE reducing conditions. |
NCBI Full Name: | P2X purinoceptor 4 |
NCBI Synonym Full Names: | purinergic receptor P2X 4 |
NCBI Official Symbol: | P2RX4 |
NCBI Official Synonym Symbols: | P2X4; P2X4R |
NCBI Protein Information: | P2X purinoceptor 4 |
UniProt Protein Name: | P2X purinoceptor 4 |
UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
Protein Family: | P2X purinoceptor |
UniProt Gene Name: | P2RX4 |
UniProt Entry Name: | P2RX4_HUMAN |