OGDH Antibody (PACO28702)
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주문- SKU:
- PACO28702
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | OGDH Antibody (PACO28702) |
Antibody SKU: | PACO28702 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 2-oxoglutarate dehydrogenase, mitochondrial protein (41-423AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO28702 at dilution of 1:100. |
Background: | The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). |
Synonyms: | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase), OGDH |
UniProt Protein Function: | OGDH: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - lysine degradation; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; EC 1.2.4.2 Chromosomal Location of Human Ortholog: 7p14-p13 Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial membrane; cytosol; oxoglutarate dehydrogenase complex Molecular Function:chaperone binding; metal ion binding; heat shock protein binding; thiamin pyrophosphate binding; oxoglutarate dehydrogenase (succinyl-transferring) activity Biological Process: generation of precursor metabolites and energy; glycolysis; striatum development; succinyl-CoA metabolic process; tricarboxylic acid cycle; hippocampus development; pyramidal neuron development; thalamus development; 2-oxoglutarate metabolic process; cellular metabolic process; cerebellar cortex development; tangential migration from the subventricular zone to the olfactory bulb; NADH metabolic process; lysine catabolic process Disease: Alpha-ketoglutarate Dehydrogenase Deficiency |
NCBI Summary: | This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009] |
UniProt Code: | Q02218 |
NCBI GenInfo Identifier: | 160332299 |
NCBI Gene ID: | 4967 |
NCBI Accession: | Q02218.3 |
UniProt Secondary Accession: | Q02218,Q96DD3, Q9UDX0, B4E2U9, D3DVL0, E9PBM1, |
UniProt Related Accession: | Q02218 |
Molecular Weight: | 1023 |
NCBI Full Name: | 2-oxoglutarate dehydrogenase, mitochondrial |
NCBI Synonym Full Names: | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
NCBI Official Symbol: | OGDH |
NCBI Official Synonym Symbols: | E1k; OGDC; AKGDH |
NCBI Protein Information: | 2-oxoglutarate dehydrogenase, mitochondrial; OGDC-E1; oxoglutarate decarboxylase; 2-oxoglutarate dehydrogenase complex component E1; oxoglutarate dehydrogenase (succinyl-transferring) |
UniProt Protein Name: | 2-oxoglutarate dehydrogenase, mitochondrial |
UniProt Synonym Protein Names: | 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase |
UniProt Gene Name: | OGDH |
UniProt Entry Name: | ODO1_HUMAN |
Antibodies | ELISA Kits |
Anti-OGDH Antibody (CAB12477) | Human OGDH ELISA Kit |
Anti-OGDH Antibody (CAB6391) | Human 2-oxoglutarate dehydrogenase, mitochondrial (OGDH) ELISA Kit |
OGDH Antibody (PACO10995) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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