NRP2 Antibody (PACO20081)
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주문- SKU:
- PACO20081
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NRP2 Antibody (PACO20081) |
Antibody SKU: | PACO20081 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human NRP2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20081(NRP2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. |
Synonyms: | neuropilin 2 |
UniProt Protein Function: | NRP2: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Heterodimer with NRP1. Binds PLXNB1. Belongs to the neuropilin family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q33.3 Cellular Component: extracellular region; integral to membrane; membrane; plasma membrane Molecular Function:cytokine binding; growth factor binding; heparin binding; metal ion binding; receptor activity; semaphorin receptor activity; vascular endothelial growth factor receptor activity Biological Process: angiogenesis; axon extension involved in axon guidance; axon guidance; cell adhesion; nerve development; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60462 |
NCBI GenInfo Identifier: | 215274096 |
NCBI Gene ID: | 8828 |
NCBI Accession: | O60462.2 |
UniProt Secondary Accession: | O60462,O14820, O14821, Q53TQ4, Q53TS3, Q7LBX7, Q9H2D4 Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, E9PF66, |
UniProt Related Accession: | O60462 |
Molecular Weight: | 62,458 Da |
NCBI Full Name: | Neuropilin-2 |
NCBI Synonym Full Names: | neuropilin 2 |
NCBI Official Symbol: | NRP2 |
NCBI Official Synonym Symbols: | NP2; NPN2; PRO2714; VEGF165R2 |
NCBI Protein Information: | neuropilin-2 |
UniProt Protein Name: | Neuropilin-2 |
UniProt Synonym Protein Names: | Vascular endothelial cell growth factor 165 receptor 2 |
Protein Family: | Neuropilin |
UniProt Gene Name: | NRP2 |
UniProt Entry Name: | NRP2_HUMAN |
Antibodies |
Anti-NRP2 Antibody (CAB12758) |
Anti-NRP2 Antibody (CAB2581) |
NRP2 Antibody (PACO01941) |
NRP2 Antibody (PACO03165) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |