NRAS Antibody (PACO49810)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO49810
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NRAS Antibody (PACO49810) |
Antibody SKU: | PACO49810 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human GTPase NRas protein (1-186AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human brain tissue using PACO49810 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO49810 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
Synonyms: | GTPase NRas (Transforming protein N-Ras), NRAS, HRAS1 |
UniProt Protein Function: | NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric; G protein; G protein, monomeric, Ras Chromosomal Location of Human Ortholog: 1p13.2 Cellular Component: Golgi apparatus; membrane; plasma membrane Molecular Function:protein complex binding Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; Ras protein signal transduction; stimulatory C-type lectin receptor signaling pathway Disease: Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal; Noonan Syndrome 6; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular |
NCBI Summary: | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] |
UniProt Code: | P01111 |
NCBI GenInfo Identifier: | 131883 |
NCBI Gene ID: | 4893 |
NCBI Accession: | P01111.1 |
UniProt Secondary Accession: | P01111,Q14971, Q15104, Q15282, |
UniProt Related Accession: | P01111 |
Molecular Weight: | 21,229 Da |
NCBI Full Name: | GTPase NRas |
NCBI Synonym Full Names: | neuroblastoma RAS viral oncogene homolog |
NCBI Official Symbol: | NRAS |
NCBI Official Synonym Symbols: | NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1 |
NCBI Protein Information: | GTPase NRas |
UniProt Protein Name: | GTPase NRas |
UniProt Synonym Protein Names: | Transforming protein N-Ras |
Protein Family: | GTPase |
UniProt Gene Name: | NRAS |
UniProt Entry Name: | RASN_HUMAN |