NR2E1 Antibody (PACO44590)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44590
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NR2E1 Antibody (PACO44590) |
Antibody SKU: | PACO44590 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Nuclear receptor subfamily 2 group E member 1 protein (106-385AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: NR2E1antibody at 3.2µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 43, 47 kDa. Observed band size: 43 kDa.. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO44590 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO44590 at dilution of 1:100. |
Background: | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid, receptor (RAR) regulation in retinal cells. |
Synonyms: | Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll), NR2E1, TLX |
UniProt Protein Function: | NR2E1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Belongs to the nuclear hormone receptor family. NR2 subfamily. |
UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 6q21 Cellular Component: nucleoplasm Molecular Function:zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity Biological Process: extracellular matrix organization and biogenesis; behavioral fear response; somatic stem cell maintenance; regulation of timing of neuron differentiation; regulation of dendrite morphogenesis; amygdala development; negative regulation of transcription from RNA polymerase II promoter; cerebral cortex neuron differentiation; visual perception; layer formation in the cerebral cortex; transcription initiation from RNA polymerase II promoter; nervous system development; cell fate commitment; dentate gyrus development; generation of neurons in the forebrain; olfactory bulb development; positive regulation of cell cycle; social behavior; positive regulation of angiogenesis; negative regulation of neuron differentiation; anterior commissure morphogenesis; retina development in camera-type eye; negative regulation of astrocyte differentiation; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of apoptosis |
NCBI Summary: | The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q9Y466 |
NCBI GenInfo Identifier: | 9910804 |
NCBI Gene ID: | 7101 |
NCBI Accession: | Q9Y466.1 |
UniProt Secondary Accession: | Q9Y466,Q6ZMP8, |
UniProt Related Accession: | Q9Y466 |
Molecular Weight: | 385 |
NCBI Full Name: | Nuclear receptor subfamily 2 group E member 1 |
NCBI Synonym Full Names: | nuclear receptor subfamily 2, group E, member 1 |
NCBI Official Symbol: | NR2E1 |
NCBI Official Synonym Symbols: | TLL; TLX; XTLL |
NCBI Protein Information: | nuclear receptor subfamily 2 group E member 1; tailless homolog; nuclear receptor TLX; tailes-related receptor; protein tailless homolog |
UniProt Protein Name: | Nuclear receptor subfamily 2 group E member 1 |
UniProt Synonym Protein Names: | Nuclear receptor TLX; Protein tailless homolog; Tll; hTll |
Protein Family: | Nuclear receptor subfamily |
UniProt Gene Name: | NR2E1 |
UniProt Entry Name: | NR2E1_HUMAN |