NPY1R Antibody (PACO18774)
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주문- SKU:
- PACO18774
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NPY1R Antibody (PACO18774) |
Antibody SKU: | PACO18774 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Rat |
Immunogen: | Synthetic peptide of human NPY1R |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18774(NPY1R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Human leiomyosarcoma tissue, Primary antibody: PACO18774(NPY1R Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18774(NPY1R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle |
Synonyms: | Neuropeptide Y receptor Y1 |
UniProt Protein Function: | NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 4q31.3-q32 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain |
NCBI Summary: | This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013] |
UniProt Code: | P25929 |
NCBI GenInfo Identifier: | 128997 |
NCBI Gene ID: | 4886 |
NCBI Accession: | P25929.1 |
UniProt Secondary Accession: | P25929,B2R6H5, |
UniProt Related Accession: | P25929 |
Molecular Weight: | 384 |
NCBI Full Name: | Neuropeptide Y receptor type 1 |
NCBI Synonym Full Names: | neuropeptide Y receptor Y1 |
NCBI Official Symbol: | NPY1R |
NCBI Official Synonym Symbols: | NPYR; NPY1-R |
NCBI Protein Information: | neuropeptide Y receptor type 1 |
UniProt Protein Name: | Neuropeptide Y receptor type 1 |
Protein Family: | Neuropeptide Y receptor |
UniProt Gene Name: | NPY1R |
UniProt Entry Name: | NPY1R_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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