UniProt Protein Function: | ANPB: natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. 21 mutations linked to acromesomelic dysplasia (skeletal malformation). 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Kinase, protein; Membrane protein, integral; Lyase; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; EC 4.6.1.2; Receptor, misc.; Guanylyl cyclase; RGC group; RGC family Chromosomal Location of Human Ortholog: 9p21-p12 Cellular Component: guanylate cyclase complex, soluble; integral to membrane; plasma membrane Molecular Function:adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding; natriuretic peptide receptor activity; peptide hormone binding; protein kinase activity; receptor activity; transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; cGMP biosynthetic process; negative regulation of meiotic cell cycle; ossification; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; signal transduction Disease: Acromesomelic Dysplasia, Maroteaux Type; Epiphyseal Chondrodysplasia, Miura Type; Short Stature With Nonspecific Skeletal Abnormalities |
NCBI Summary: | This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008] |
UniProt Code: | P20594 |
NCBI GenInfo Identifier: | 113916 |
NCBI Gene ID: | 4882 |
NCBI Accession: | P20594.1 |
UniProt Secondary Accession: | P20594,O60871, Q4VAK7, Q5TCV2, Q8TA93, Q9UQ50, B0ZBF2 B0ZBF3, D3DRP3, D3DRP4, |
UniProt Related Accession: | P20594 |
Molecular Weight: | 111,208 Da |
NCBI Full Name: | Atrial natriuretic peptide receptor 2 |
NCBI Synonym Full Names: | natriuretic peptide receptor 2 |
NCBI Official Symbol: | NPR2 |
NCBI Official Synonym Symbols: | AMDM; ANPb; ECDM; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B |
NCBI Protein Information: | atrial natriuretic peptide receptor 2 |
UniProt Protein Name: | Atrial natriuretic peptide receptor 2 |
UniProt Synonym Protein Names: | Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B |
UniProt Gene Name: | NPR2 |
UniProt Entry Name: | ANPRB_HUMAN |