NME2 Antibody (PACO10874)
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주문- SKU:
- PACO10874
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NME2 Antibody (PACO10874) |
Antibody SKU: | PACO10874 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human NME2 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | non-metastatic cells 2, protein (NM23B) expressed in;NME2;MGC111212;NDPK-B;NDPKB;NM23-H2;NM23B;puf ; |
UniProt Protein Function: | NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 2.7.13.3; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Kinase, nucleoside diphosphate; Kinase, other; EC 2.7.4.6; Other group; NDK family Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: cytoplasm; cytosol; focal adhesion; lamellipodium; nucleus; ruffle Molecular Function:nucleoside diphosphate kinase activity; protein binding; transcription factor activity Biological Process: cell adhesion; integrin-mediated signaling pathway; negative regulation of apoptosis; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of epidermis development; regulation of transcription, DNA-dependent |
NCBI Summary: | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] |
UniProt Code: | P22392 |
NCBI GenInfo Identifier: | 127983 |
NCBI Gene ID: | 4831 |
NCBI Accession: | P22392.1 |
UniProt Secondary Accession: | P22392,Q1WM23, Q6LCT6, A8MWA3, |
UniProt Related Accession: | P22392 |
Molecular Weight: | 30,137 Da |
NCBI Full Name: | Nucleoside diphosphate kinase B |
NCBI Synonym Full Names: | NME/NM23 nucleoside diphosphate kinase 2 |
NCBI Official Symbol: | NME2 |
NCBI Official Synonym Symbols: | PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2 |
NCBI Protein Information: | nucleoside diphosphate kinase B |
UniProt Protein Name: | Nucleoside diphosphate kinase B |
UniProt Synonym Protein Names: | C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2 |
UniProt Gene Name: | NME2 |
UniProt Entry Name: | NDKB_HUMAN |