NES Antibody (PACO20455)
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주문- SKU:
- PACO20455
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NES Antibody (PACO20455) |
Antibody SKU: | PACO20455 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:20-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human NES |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20455(NES Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. |
Synonyms: | nestin |
UniProt Protein Function: | nestin: an intermediate filament protein. It is expressed predominantly in stem cells of the central nervous system in the neural tube. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: intermediate filament cytoskeleton; cytoplasm; intermediate filament Molecular Function:intermediate filament binding; structural molecule activity Biological Process: positive regulation of intermediate filament depolymerization; central nervous system development; negative regulation of catalytic activity; cell projection morphogenesis; brain development; negative regulation of neuron apoptosis; negative regulation of protein binding; G2/M transition of mitotic cell cycle; embryonic camera-type eye development |
NCBI Summary: | This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011] |
UniProt Code: | P48681 |
NCBI GenInfo Identifier: | 146345464 |
NCBI Gene ID: | 10763 |
NCBI Accession: | P48681.2 |
UniProt Secondary Accession: | P48681,O00552, Q3LIF5, Q5SYZ6, |
UniProt Related Accession: | P48681 |
Molecular Weight: | 1621 |
NCBI Full Name: | Nestin |
NCBI Synonym Full Names: | nestin |
NCBI Official Symbol: | NES |
NCBI Official Synonym Symbols: | Nbla00170 |
NCBI Protein Information: | nestin |
UniProt Protein Name: | Nestin |
Protein Family: | Nestin |
UniProt Gene Name: | NES |
UniProt Entry Name: | NEST_HUMAN |