NEFM Antibody (PACO20085)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO20085
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NEFM Antibody (PACO20085) |
Antibody SKU: | PACO20085 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human NEFM |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: Human brain malignant glioma tissue, Primary antibody: PACO20085(NEFM Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minutes. | |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20085(NEFM Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Synonyms: | neurofilament, medium polypeptide |
UniProt Protein Function: | NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 8p21 Cellular Component: axon; neurofilament; neuromuscular junction Molecular Function:protein binding; structural constituent of cytoskeleton; microtubule binding Biological Process: neurofilament bundle assembly; axon cargo transport; regulation of axon diameter; microtubule cytoskeleton organization and biogenesis |
NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008] |
UniProt Code: | P07197 |
NCBI GenInfo Identifier: | 281185500 |
NCBI Gene ID: | 4741 |
NCBI Accession: | P07197.3 |
UniProt Secondary Accession: | P07197,Q4QRK6, B4DGN2, E9PBF7, |
UniProt Related Accession: | P07197 |
Molecular Weight: | 59,599 Da |
NCBI Full Name: | Neurofilament medium polypeptide |
NCBI Synonym Full Names: | neurofilament, medium polypeptide |
NCBI Official Symbol: | NEFM |
NCBI Official Synonym Symbols: | NFM; NEF3; NF-M |
NCBI Protein Information: | neurofilament medium polypeptide; neurofilament 3; 160 kDa neurofilament protein; neurofilament triplet M protein; neurofilament-3 (150 kD medium); neurofilament, medium polypeptide 150kDa |
UniProt Protein Name: | Neurofilament medium polypeptide |
UniProt Synonym Protein Names: | 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein |
Protein Family: | Neurofilament medium polypeptide |
UniProt Gene Name: | NEFM |
UniProt Entry Name: | NFM_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |