NEFH Antibody (PACO20084)
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주문- SKU:
- PACO20084
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NEFH Antibody (PACO20084) |
Antibody SKU: | PACO20084 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human NEFH |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20084(NEFH Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20084(NEFH Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. |
Synonyms: | neurofilament, heavy polypeptide |
UniProt Protein Function: | NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: mitochondrion; axon; cytoplasm; neurofilament Molecular Function:protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding Biological Process: axonogenesis; neurofilament bundle assembly; microtubule cytoskeleton organization and biogenesis; cell projection biogenesis; peripheral nervous system neuron axonogenesis Disease: Amyotrophic Lateral Sclerosis 1 |
NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | P12036 |
NCBI GenInfo Identifier: | 226726294 |
NCBI Gene ID: | 4744 |
NCBI Accession: | P12036.4 |
UniProt Secondary Accession: | P12036,Q96HF8, Q9UJS7, Q9UQ14, B4DYY4, |
UniProt Related Accession: | P12036 |
Molecular Weight: | |
NCBI Full Name: | Neurofilament heavy polypeptide |
NCBI Synonym Full Names: | neurofilament, heavy polypeptide |
NCBI Official Symbol: | NEFH |
NCBI Official Synonym Symbols: | NFH |
NCBI Protein Information: | neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa |
UniProt Protein Name: | Neurofilament heavy polypeptide |
UniProt Synonym Protein Names: | 200 kDa neurofilament protein; Neurofilament triplet H protein |
Protein Family: | Neurofilament heavy polypeptide |
UniProt Gene Name: | NEFH |
UniProt Entry Name: | NFH_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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