NDUFS4 Antibody (PACO16762)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO16762
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NDUFS4 Antibody (PACO16762) |
Antibody SKU: | PACO16762 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human NDUFS4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, Mouse kidney tissue, Primary antibody: PACO16762(NDUFS4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
Background: | This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. |
Synonyms: | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa |
UniProt Protein Function: | NDUFS4: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in NDUFS4 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I NDUFS4 subunit family. |
UniProt Protein Details: | Protein type:EC 1.6.99.3; Oxidoreductase; EC 1.6.5.3; Mitochondrial; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 5q11.1 Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex I Molecular Function:NADH dehydrogenase (ubiquinone) activity Biological Process: mitochondrial respiratory chain complex I assembly; cellular metabolic process; regulation of protein amino acid phosphorylation; cAMP-mediated signaling; positive regulation of fibroblast proliferation; response to cAMP; mitochondrial electron transport, NADH to ubiquinone; cellular respiration; brain development Disease: Leigh Syndrome; Mitochondrial Complex I Deficiency |
NCBI Summary: | This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43181 |
NCBI GenInfo Identifier: | 3287881 |
NCBI Gene ID: | 4724 |
NCBI Accession: | O43181.1 |
UniProt Secondary Accession: | O43181,Q9BS69, |
UniProt Related Accession: | O43181 |
Molecular Weight: | 175 |
NCBI Full Name: | NADH dehydrogenase |
NCBI Synonym Full Names: | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) |
NCBI Official Symbol: | NDUFS4 |
NCBI Official Synonym Symbols: | AQDQ; CI-18 |
NCBI Protein Information: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-AQDQ; CI-18 kDa; complex I-AQDQ; complex I-18 kDa; complex I 18kDa subunit; NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH dehydrogenase (ubiquinone) iron-sulfur protein 4; mitochondrial respiratory chain complex I (18-KD subunit) |
UniProt Protein Name: | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial |
UniProt Synonym Protein Names: | Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit |
Protein Family: | NADH dehydrogenase [ubiquinone] iron-sulfur protein |
UniProt Gene Name: | NDUFS4 |
UniProt Entry Name: | NDUS4_HUMAN |