NDRG2 Antibody (PACO44179)
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주문- SKU:
- PACO44179
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NDRG2 Antibody (PACO44179) |
Antibody SKU: | PACO44179 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Protein NDRG2 protein (152-371AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: NDRG2 antibody at 4.02µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 41, 40, 37, 38 kDa. Observed band size: 41 kDa.. | |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44179 at dilution of 1:100. |
Background: | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. |
Synonyms: | Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613) [Cleaved into: Protein NDRG2, N-terminally processed], NDRG2, KIAA1248 SYLD |
UniProt Protein Function: | NDRG2: a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease |
UniProt Protein Details: | Protein type:Tumor suppressor; Apoptosis Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; cytosol Molecular Function:protein binding Biological Process: Wnt receptor signaling pathway; substantia nigra development; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation |
NCBI Summary: | This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UN36 |
NCBI GenInfo Identifier: | 20141615 |
NCBI Gene ID: | 57447 |
NCBI Accession: | Q9UN36.2 |
UniProt Secondary Accession: | Q9UN36,Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, B3KUE3 B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, |
UniProt Related Accession: | Q9UN36 |
Molecular Weight: | 371 |
NCBI Full Name: | Protein NDRG2 |
NCBI Synonym Full Names: | NDRG family member 2 |
NCBI Official Symbol: | NDRG2 |
NCBI Official Synonym Symbols: | SYLD |
NCBI Protein Information: | protein NDRG2; syld709613 protein; cytoplasmic protein Ndr1; NDR1-related protein NDR2; N-myc downstream regulator 2; N-myc downstream-regulated gene 2 protein |
UniProt Protein Name: | Protein NDRG2 |
UniProt Synonym Protein Names: | N-myc downstream-regulated gene 2 protein; Protein Syld709613 |
Protein Family: | Protein |
UniProt Gene Name: | NDRG2 |
UniProt Entry Name: | NDRG2_HUMAN |