NCR2 Antibody (PACO19416)
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주문- SKU:
- PACO19416
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NCR2 Antibody (PACO19416) |
Antibody SKU: | PACO19416 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human NCR2 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19416(NCR2 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19416(NCR2 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Natural cytotoxicity triggering receptor 2 is a protein that in humans is encoded by the NCR2 gene. NCR2 has also been designated as CD336 (cluster of differentiation 336). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load. |
Synonyms: | natural cytotoxicity triggering receptor 2 |
UniProt Protein Function: | NCR2: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: innate immune response; cellular defense response; signal transduction |
UniProt Code: | O95944 |
NCBI GenInfo Identifier: | 251757303 |
NCBI Gene ID: | 9436 |
NCBI Accession: | O95944.2 |
UniProt Secondary Accession: | O95944,Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2, |
UniProt Related Accession: | O95944 |
Molecular Weight: | 276 |
NCBI Full Name: | Natural cytotoxicity triggering receptor 2 |
NCBI Synonym Full Names: | natural cytotoxicity triggering receptor 2 |
NCBI Official Symbol: | NCR2 |
NCBI Official Synonym Symbols: | LY95; CD336; NKP44; NK-p44; dJ149M18.1 |
NCBI Protein Information: | natural cytotoxicity triggering receptor 2; NK cell-activating receptor; NK cell activating receptor (NKp44); natural killer cell p44-related protein; lymphocyte antigen 95 (activating NK-receptor; NK-p44); lymphocyte antigen 95 homolog (activating NK-rec |
UniProt Protein Name: | Natural cytotoxicity triggering receptor 2 |
UniProt Synonym Protein Names: | Lymphocyte antigen 95 homolog; NK cell-activating receptor; Natural killer cell p44-related protein; NK-p44; NKp44; CD_antigen: CD336 |
Protein Family: | Natural cytotoxicity triggering receptor |
UniProt Gene Name: | NCR2 |
UniProt Entry Name: | NCTR2_HUMAN |
Antibodies | ELISA Kits |
Anti-NCR2 Antibody (CAB3657) | Human NKp44/NCR2(Natural cytotoxicity triggering receptor 2) ELISA Kit |
NCR2 Antibody (PACO02156) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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