NCL Antibody (PACO44015)
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주문- SKU:
- PACO44015
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NCL Antibody (PACO44015) |
Antibody SKU: | PACO44015 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Nucleolin protein (411-710AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: NCL antibody at 8µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: Hela whole cell lysate. Lane 3: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 77 kDa. Observed band size: 77 kDa.. | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO44015 at dilution of 1:100. |
Background: | Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. |
Synonyms: | Nucleolin (Protein C23), NCL |
UniProt Protein Function: | NCL: the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly. |
UniProt Protein Details: | Protein type:Helicase; RNA-binding; Nucleolus; Nuclear receptor co-regulator; DNA-binding Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: cell cortex; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex Molecular Function:identical protein binding; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding Biological Process: angiogenesis |
NCBI Summary: | Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] |
UniProt Code: | P19338 |
NCBI GenInfo Identifier: | 90110781 |
NCBI Gene ID: | 4691 |
NCBI Accession: | P19338.3 |
UniProt Secondary Accession: | P19338,Q53SK1, Q8NB06, Q9UCF0, Q9UDG1, |
UniProt Related Accession: | P19338 |
Molecular Weight: | 76,614 Da |
NCBI Full Name: | Nucleolin |
NCBI Synonym Full Names: | nucleolin |
NCBI Official Symbol: | NCL |
NCBI Official Synonym Symbols: | C23 |
NCBI Protein Information: | nucleolin |
UniProt Protein Name: | Nucleolin |
UniProt Synonym Protein Names: | Protein C23 |
Protein Family: | Nucleolin |
UniProt Gene Name: | NCL |
UniProt Entry Name: | NUCL_HUMAN |