NCKAP1L Antibody (PACO10758)
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주문- SKU:
- PACO10758
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NCKAP1L Antibody (PACO10758) |
Antibody SKU: | PACO10758 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human NCKAP1L |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | 128kd; |
UniProt Protein Function: | HEM1: a component of the Scar/WAVE complex that plays an important role in regulating cell shape and motility. Found at elevated levels in cells of hematopoietic lineage. Localizes to propagating waves at the leading edge of a motile human neutrophils. The complex stimulates actin assembly; polymerized actin is reciprocally required to remove the complex from the membrane. Overexpression is associated with poor outcome in B-cell chronic lymphocytic leukemia patients.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12q13.1Cellular Component: cytosol; membraneMolecular Function: GTPase activator activity; protein binding; protein complex binding; protein kinase activator activityBiological Process: B cell homeostasis; B cell receptor signaling pathway; chemotaxis; cortical actin cytoskeleton organization and biogenesis; erythrocyte development; maintenance of cell polarity; myeloid cell homeostasis; negative regulation of apoptosis; negative regulation of interleukin-17 production; negative regulation of interleukin-6 production; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of B cell differentiation; positive regulation of B cell proliferation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of cell adhesion mediated by integrin; positive regulation of erythrocyte differentiation; positive regulation of gamma-delta T cell differentiation; positive regulation of lymphocyte differentiation; positive regulation of phagocytosis, engulfment; positive regulation of phosphorylation; positive regulation of T cell proliferation; protein complex assembly; response to drug; T cell homeostasis; vascular endothelial growth factor receptor signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] |
UniProt Code: | P55160 |
NCBI GenInfo Identifier: | 218512111 |
NCBI Gene ID: | 3071 |
NCBI Accession: | P55160.3 |
UniProt Secondary Accession: | P55160,Q52LW0, B4DUT5 |
UniProt Related Accession: | P55160 |
Molecular Weight: | 122,478 Da |
NCBI Full Name: | Nck-associated protein 1-like |
NCBI Synonym Full Names: | NCK associated protein 1 like |
NCBI Official Symbol: | NCKAP1L |
NCBI Official Synonym Symbols: | HEM1 |
NCBI Protein Information: | nck-associated protein 1-like |
UniProt Protein Name: | Nck-associated protein 1-like |
UniProt Synonym Protein Names: | Hematopoietic protein 1; Membrane-associated protein HEM-1 |
Protein Family: | Nck-associated protein |
UniProt Gene Name: | NCKAP1L |
UniProt Entry Name: | NCKPL_HUMAN |