NCKAP1 Antibody (PACO20069)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO20069
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | NCKAP1 Antibody (PACO20069) |
Antibody SKU: | PACO20069 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human NCKAP1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20069(NCKAP1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | NAP125, also known as NCKAP1 (NCK-associated protein 1), p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid, single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease (AD)-affected brains, suggesting a possible role in the disease. |
Synonyms: | NCK-associated protein 1 |
UniProt Protein Function: | NCKAP1: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Belongs to the HEM-1/HEM-2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q32 Cellular Component: focal adhesion; integral to membrane; cytosol Molecular Function:protein binding; Rac GTPase binding; protein complex binding Biological Process: lamellipodium biogenesis; somitogenesis; central nervous system development; basal protein localization; zygotic determination of anterior/posterior axis, embryo; protein stabilization; in utero embryonic development; apoptosis; Rac protein signal transduction; paraxial mesoderm morphogenesis; mesodermal cell migration; notochord morphogenesis; apical protein localization; embryonic body morphogenesis; regulation of protein localization; embryonic foregut morphogenesis; establishment and/or maintenance of actin cytoskeleton polarity; neural tube closure; embryonic heart tube development; innate immune response; vascular endothelial growth factor receptor signaling pathway; cell migration involved in gastrulation; endoderm development |
UniProt Code: | Q9Y2A7 |
NCBI GenInfo Identifier: | 12643947 |
NCBI Gene ID: | 10787 |
NCBI Accession: | Q9Y2A7.1 |
UniProt Secondary Accession: | Q9Y2A7,O60329, Q53QN5, Q53S94, Q53Y35, |
UniProt Related Accession: | Q9Y2A7 |
Molecular Weight: | 129,517 Da |
NCBI Full Name: | Nck-associated protein 1 |
NCBI Synonym Full Names: | NCK-associated protein 1 |
NCBI Official Symbol: | NCKAP1 |
NCBI Official Synonym Symbols: | HEM2; NAP1; NAP125; p125Nap1 |
NCBI Protein Information: | nck-associated protein 1; membrane-associated protein HEM-2 |
UniProt Protein Name: | Nck-associated protein 1 |
UniProt Synonym Protein Names: | Membrane-associated protein HEM-2; p125Nap1 |
Protein Family: | Nck-associated protein |
UniProt Gene Name: | NCKAP1 |
UniProt Entry Name: | NCKP1_HUMAN |