NAPSA Antibody (PACO15490)
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주문- SKU:
- PACO15490
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NAPSA Antibody (PACO15490) |
Antibody SKU: | PACO15490 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human NAPSA |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15490(NAPSA Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15490(NAPSA Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. |
Synonyms: | napsin A aspartic peptidase |
UniProt Protein Function: | NAPSA: May be involved in processing of pneumocyte surfactant precursors. Belongs to the peptidase A1 family. |
UniProt Protein Details: | Protein type:EC 3.4.23.-; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space; lysosome Molecular Function:aspartic-type endopeptidase activity; endopeptidase activity; peptidase activity Biological Process: cellular protein metabolic process; membrane protein proteolysis; protein catabolic process; surfactant homeostasis |
NCBI Summary: | This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016] |
UniProt Code: | O96009 |
NCBI GenInfo Identifier: | 6225749 |
NCBI Gene ID: | 9476 |
NCBI Accession: | O96009.1 |
UniProt Secondary Accession: | O96009,Q8WWD9, |
UniProt Related Accession: | O96009 |
Molecular Weight: | 45,387 Da |
NCBI Full Name: | Napsin-A |
NCBI Synonym Full Names: | napsin A aspartic peptidase |
NCBI Official Symbol: | NAPSA |
NCBI Official Synonym Symbols: | KAP; Kdap; NAP1; NAPA; SNAPA |
NCBI Protein Information: | napsin-A |
UniProt Protein Name: | Napsin-A |
UniProt Synonym Protein Names: | Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02 |
Protein Family: | Napsin |
UniProt Gene Name: | NAPSA |
Antibodies |
Anti-NAPSA Antibody (CAB5594) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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