NAE1 Antibody (PACO15485)
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주문- SKU:
- PACO15485
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | NAE1 Antibody (PACO15485) |
Antibody SKU: | PACO15485 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human NAE1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal muscle tissue, Human kidney tissue, Human liver tissue, Primary antibody: PACO15485(NAE1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
Background: | The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. |
Synonyms: | NEDD8 activating enzyme E1 subunit 1 |
UniProt Protein Function: | APPBP1: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 16q22 Cellular Component: cytoplasm; plasma membrane; nucleus; cytosol Molecular Function:NEDD8 activating enzyme activity; protein binding; protein heterodimerization activity; ubiquitin protein ligase binding Biological Process: regulation of apoptosis; neuron apoptosis; protein neddylation; regulation of neuron apoptosis; mitotic cell cycle DNA replication checkpoint; signal transduction |
NCBI Summary: | The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13564 |
NCBI GenInfo Identifier: | 50400302 |
NCBI Gene ID: | 8883 |
NCBI Accession: | Q13564.1 |
UniProt Related Accession: | Q13564 |
Molecular Weight: | |
NCBI Full Name: | NEDD8-activating enzyme E1 regulatory subunit |
NCBI Synonym Full Names: | NEDD8 activating enzyme E1 subunit 1 |
NCBI Official Symbol: | NAE1 |
NCBI Official Synonym Symbols: | HPP1; ula-1; APPBP1; A-116A10.1 |
NCBI Protein Information: | NEDD8-activating enzyme E1 regulatory subunit |
UniProt Protein Name: | NEDD8-activating enzyme E1 regulatory subunit |
UniProt Synonym Protein Names: | Amyloid beta precursor protein-binding protein 1, 59 kDa; APP-BP1; Amyloid protein-binding protein 1; Proto-oncogene protein 1 |
UniProt Gene Name: | NAE1 |
UniProt Entry Name: | ULA1_HUMAN |