MYF6 Antibody (PACO51726)
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주문- SKU:
- PACO51726
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | MYF6 Antibody (PACO51726) |
Antibody SKU: | PACO51726 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Recombinant Human Myogenic factor 6 protein (26-232AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: HepG2 whole cell lysate, HEK293 whole cell lysate, A549 whole cell lysate, Mouse brain tissue, Mouse skeletal muscle tissue, Rat heart tissue, Rat liver tissue. All lanes: MYF6 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 27 kDa. Observed band size: 37 kDa.. | |
Immunofluorescent analysis of Hela cells using PACO51726 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO51726 at dilution of 1:100. |
Background: | Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. |
Synonyms: | Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4), MYF6, BHLHC4 MRF4 |
UniProt Protein Function: | Myf-6: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Defects in MYF6 may be a cause of centronuclear myopathy type 3 (CNM3). A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q21 Cellular Component: nucleoplasm; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein heterodimerization activity; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; muscle cell differentiation; skeletal muscle development; somitogenesis; positive regulation of skeletal muscle fiber development; muscle cell fate commitment; positive regulation of muscle cell differentiation; skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of myoblast differentiation Disease: Myopathy, Centronuclear, 3 |
NCBI Summary: | The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010] |
UniProt Code: | P23409 |
NCBI GenInfo Identifier: | 4505299 |
NCBI Gene ID: | 4618 |
NCBI Accession: | NP_002460.1 |
UniProt Secondary Accession: | P23409,Q53X80, Q6FHI9, B2R898, |
UniProt Related Accession: | P23409 |
Molecular Weight: | |
NCBI Full Name: | myogenic factor 6 |
NCBI Synonym Full Names: | myogenic factor 6 (herculin) |
NCBI Official Symbol: | MYF6 |
NCBI Official Synonym Symbols: | CNM3; MRF4; myf-6; bHLHc4 |
NCBI Protein Information: | myogenic factor 6 |
UniProt Protein Name: | Myogenic factor 6 |
UniProt Synonym Protein Names: | Class C basic helix-loop-helix protein 4; bHLHc4; Muscle-specific regulatory factor 4 |
Protein Family: | Myogenic factor |
UniProt Gene Name: | MYF6 |
UniProt Entry Name: | MYF6_HUMAN |
Antibodies | ELISA Kits |
Anti-MYF6 Antibody (CAB15291) | MYF6 Colorimetric Cell-Based ELISA |
MYF6 Antibody (PACO01122) | |
MYF6 Antibody (PACO10678) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |