MYBPC3 Antibody (PACO48566)
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주문- SKU:
- PACO48566
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MYBPC3 Antibody (PACO48566) |
Antibody SKU: | PACO48566 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Myosin-binding protein C, cardiac-type protein (1-328AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Mouse heart tissue. All lanes: MYBPC-3 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 141 kDa. Observed band size: 141 kDa.. |
Background: | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
Synonyms: | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform), MYBPC3 |
UniProt Protein Function: | MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. |
UniProt Protein Details: | Protein type:Myosin-binding Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: A band; cytosol; sarcomere; striated muscle thick filament Molecular Function:ATPase activator activity; identical protein binding; myosin binding; myosin heavy chain binding; protein binding; structural constituent of muscle Biological Process: cardiac muscle contraction; heart morphogenesis; muscle filament sliding; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis Disease: Cardiomyopathy, Familial Hypertrophic, 4; Left Ventricular Noncompaction 10 |
NCBI Summary: | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14896 |
NCBI GenInfo Identifier: | 425906074 |
NCBI Gene ID: | 4607 |
NCBI Accession: | Q14896.4 |
UniProt Secondary Accession: | Q14896,Q16410, Q6R2F7, Q9UE27, Q9UM53, A5PL00, |
UniProt Related Accession: | Q14896 |
Molecular Weight: | 140,703 Da |
NCBI Full Name: | Myosin-binding protein C, cardiac-type |
NCBI Synonym Full Names: | myosin binding protein C, cardiac |
NCBI Official Symbol: | MYBPC3 |
NCBI Official Synonym Symbols: | FHC; CMH4; CMD1MM; LVNC10; MYBP-C |
NCBI Protein Information: | myosin-binding protein C, cardiac-type |
UniProt Protein Name: | Myosin-binding protein C, cardiac-type |
UniProt Synonym Protein Names: | C-protein, cardiac muscle isoform |
Protein Family: | Myosin-binding protein |
UniProt Gene Name: | MYBPC3 |
UniProt Entry Name: | MYPC3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |