MTTP Antibody (PACO47562)
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주문- SKU:
- PACO47562
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MTTP Antibody (PACO47562) |
Antibody SKU: | PACO47562 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Microsomal triglyceride transfer protein large subunit protein (19-151AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO47562 at dilution of 1:100. | |
Immunofluorescent analysis of HepG2 cells using PACO47562 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO47562 at dilution of 1:100. |
Background: | Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. |
Synonyms: | Microsomal triglyceride transfer protein large subunit, MTTP, MTP |
UniProt Protein Function: | MTTP: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Defects in MTTP are the cause of abetalipoproteinemia (ABL). ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. |
UniProt Protein Details: | Protein type:Endoplasmic reticulum Chromosomal Location of Human Ortholog: 4q24 Cellular Component: endoplasmic reticulum lumen; receptor complex Molecular Function:lipid transporter activity; lipid binding Biological Process: lipoprotein metabolic process; lipid metabolic process; lipid transport Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia |
NCBI Summary: | MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P55157 |
NCBI GenInfo Identifier: | 1709167 |
NCBI Gene ID: | 4547 |
NCBI Accession: | P55157.1 |
UniProt Secondary Accession: | P55157,Q08AM4, Q6P5T3, A8K428, |
UniProt Related Accession: | P55157 |
Molecular Weight: | 894 |
NCBI Full Name: | Microsomal triglyceride transfer protein large subunit |
NCBI Synonym Full Names: | microsomal triglyceride transfer protein |
NCBI Official Symbol: | MTTP |
NCBI Official Synonym Symbols: | ABL; MTP |
NCBI Protein Information: | microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein (large polypeptide, 88kDa) |
UniProt Protein Name: | Microsomal triglyceride transfer protein large subunit |
Protein Family: | Microsomal triglyceride transfer protein |
UniProt Gene Name: | MTTP |
UniProt Entry Name: | MTP_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |