MSH5 Antibody (PACO14722)
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주문- SKU:
- PACO14722
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MSH5 Antibody (PACO14722) |
Antibody SKU: | PACO14722 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human MSH5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO14722(MSH5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). | |
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, U937 cells, Primary antibody: PACO14722(MSH5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14722(MSH5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. |
Synonyms: | mutS homolog 5 |
UniProt Protein Function: | MSH5: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis. Belongs to the DNA mismatch repair MutS family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: synaptonemal complex Molecular Function:damaged DNA binding; mismatched DNA binding; protein binding Biological Process: chiasma formation; meiotic mismatch repair; mismatch repair |
NCBI Summary: | This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011] |
UniProt Code: | O43196 |
NCBI GenInfo Identifier: | 3914060 |
NCBI Gene ID: | 4439 |
NCBI Accession: | O43196.1 |
UniProt Secondary Accession: | O43196,O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7, B0V033 B0V034, |
UniProt Related Accession: | O43196 |
Molecular Weight: | 91,862 Da |
NCBI Full Name: | MutS protein homolog 5 |
NCBI Synonym Full Names: | mutS homolog 5 |
NCBI Official Symbol: | MSH5 |
NCBI Official Synonym Symbols: | G7; NG23; MUTSH5 |
NCBI Protein Information: | mutS protein homolog 5 |
UniProt Protein Name: | MutS protein homolog 5 |
Protein Family: | MutS protein |
UniProt Gene Name: | MSH5 |
UniProt Entry Name: | MSH5_HUMAN |
Antibodies |
Anti-MSH5 Antibody (CAB10121) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |