MSH4 Antibody (PACO28398)
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주문- SKU:
- PACO28398
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | MSH4 Antibody (PACO28398) |
Antibody SKU: | PACO28398 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human MutS protein homolog 4 protein (501-800AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot Positive WB detected in: Mouse lung tissue, Mouse kidney tissue, Human placenta tissue All lanes: MSH4 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 105 kDa Observed band size: 105 kDa . | |
Immunofluorescent analysis of Hela cells using PACO28398 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO28398 at dilution of 1:100. |
Background: | Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. |
Synonyms: | MutS protein homolog 4 (hMSH4), MSH4 |
UniProt Protein Function: | MSH4: Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Belongs to the DNA mismatch repair MutS family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1p31.1 Cellular Component: nuclear chromosome; nucleus Molecular Function:damaged DNA binding; DNA binding; mismatched DNA binding; protein binding Biological Process: meiotic mismatch repair; meiotic recombination; mismatch repair |
NCBI Summary: | This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011] |
UniProt Code: | O15457 |
NCBI GenInfo Identifier: | 2463653 |
NCBI Gene ID: | 4438 |
NCBI Accession: | AAB72039.1 |
UniProt Secondary Accession: | O15457,Q5T4U6, Q8NEB3, Q9UNP8, |
UniProt Related Accession: | O15457 |
Molecular Weight: | 104,756 Da |
NCBI Full Name: | MSH4 |
NCBI Synonym Full Names: | mutS homolog 4 |
NCBI Official Symbol: | MSH4 |
NCBI Protein Information: | mutS protein homolog 4 |
UniProt Protein Name: | MutS protein homolog 4 |
Protein Family: | MutS protein |
UniProt Gene Name: | MSH4 |